What is the ROC Plotter?
The ROC plotter is capable to validate the predictive power of 54,675 genes in 3,104 breast cancer patients.
Prognostic or predictive biomarker?
A biomarker can be either prognostic or predictive. A prognostic marker predicts the natural history of disease, independent of treatment. It can indicate a need for further treatment, but does not help to determine which treatment. A predictive marker predicts benefit from a specific treatment; it helps to select a particular treatment over another.
What treatments are available?
hormonal therapy (n=971 patients)
anti-HER2 therapy (n=267 patients)
chemotherapy (n=2,108 patients)
Which genes can I use?
ROC plotter recognizes 70,632 gene symbols (including HUGO Gene Nomenclature Committee approved official gene symbols, previous symbols and aliases) and 54,675 Affymetrix probe set IDs. All these are listed in the results page. As the different names can overlap, we recommend to cross-check the identity of the selected gene.
What is the JetSet probe?
JetSet is a tool to select the optimal microarray probe set to represent a gene. More info on the JetSet homepage.
Can I use multiple genes?
Yes. Maximum 20 genes are allowed.
Want to check for prognostic biomarkers?
We recommend to use the KM-plotter to check the prognostic power of any gene in breast cancer.